By John G. Bartlett
Designed to supply easy accessibility to the factors with which to struggle infectious ailment through targeting choice, right doses, expenses, and unintended effects of antimicrobial brokers, the 2004 notebook of Infectious illness remedy attracts commonly from innovations made via the facilities for ailment regulate, the clinical Letter, the yank health facility Formulary provider, and the AMA's Drug reviews. Tabular fabric has been up to date to incorporate all newly authorized antibiotics, in addition to new innovations for administration.
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Extra info for 2004 Pocket Book of Infectious Disease Therapy
0 Gg/mL) Pneumonia Telithromycin; † fluoroquinolone (6); vancomycin; linezolid Quinupristin-dalfopristin; daptomycin S. 2 mil units/d) + strep (1 g/d) × 2 wks Maintenance: TMP-SMX (1 DS/d) or doxycycline/minocycline (200 mg/d × 1 yr) Ureaplasma urealyticum Genital tract infection Doxycycline (200 mg/d × 7 d) Macrolides (8) Vibrio cholerae (Lancet 2003;361:231) Cholera (see p 274) Doxycycline (300 mg × 1); tetracycline (500 mg qid × 3 d) Fluoroquinolone-single dose Vibrio parahaemolyticus (CI D 2001;32:331) Diarrhea (usually not treated) (see p 275) Tetracycline (4) Fluoroquinolone (6) Vibrio vulnificus (CI D 2003;37:272) Septicemia Wound infection Gastroenteritis Tetracycline (4) Cefotaxime/Ceftriaxone Chloramphenicol Aminoglycoside Enterocolitis and mesenteric adenitis (usually not treated) Sulfa-trimethoprim; gentamicin; fluoroquinolone (6); doxycycline Cephalosporin (3rd gen) (5) Septicemia Aminoglycoside (gentamicin) Chloramphenicol; ciprofloxacin; sulfa-trimethoprim Plague treatment Streptomycin; gentamicin Chloramphenicol; tetracycline (4); ciprofloxacin Prevention Doxycycline Ciprofloxacin Chloramphenicol Mesenteric adenitis (usually not treated) Septicemia Aminoglycoside (1) Ampicillin Sulfa-trimethoprim; tetracycline (4) Xanthomonas maltophilia (see Stenotrophomonas maltophila ) Yersinia enterocolitica (CI D 2001;32:331) Yersinia pestis (JAMA 2000;283:2281) Yersinia pseudo-tuberculosis 1 2 3 4 5 .
Aminoglycosides: gentamicin, tobramycin, amikacin, netilimicin. S. Antipseudomonad penicillin: ticarcillin, piperacillin. Penicillinase-resistant penicillins: nafcillin, oxacillin, methicillin, cloxacillin, dicloxacillin. Tetracycline: Tetracycline, doxycycline, minocycline. Cephalosporins and miscellaneous beta-lactams 1st generation: Cefadroxil*, cefazolin, cephalexin,* cephapirin, cephradine* 2nd generation: Cefaclor,* cefaclor ER, cefamandole, ceforanide, cefotetan, cefoxitin, cefuroxime,* cefprozil,* loracarbef* 3rd generation: Cefotaxime, ceftizoxime, ceftazidime, cefoperazone, ceftriaxone, moxalactam, cefixime,* cefpodoxime,* cefdinir,* cefditoren,* ceftibuten* 4th generation: Cefepime Cephamycins: Cefoxitin, cefotetan Monobactam: Aztreonam Carbapenem: I mipenem, meropenem, ertapenem Carbacephem: Loracarbef* 6 .
2 g/d — Usual Usual Half dose Rifampin Late 2 Hepatic Early 2–5 2–5 600 mg/d 600 mg/d Usual Usual Usual Rifapentine Hepatic 16–19h — 600 mg 2×/wk — Usual Usual Usual Rimantadine Hepatic 24–30 48–60 100 mg bid — Usual Usual 100 mg/d Spectinomycin Renal 1–3 ? 125 g po q6h g q6h — 15 mg/kg q12h 1 g q24h 1 g q3–10d 1 g q5–10d Voriconazole Hepatic — — 200 mg q12h 6 mg/kg q12h ×2, then 4 mg/kg q12h Usual po-usual IV-not recommended po-usual IV-not recommended Zanamivir Renal 3 18 10 mg bid — Usual No data No data inhaled * Half life in serum IC = intracellular half life.